Modelling of ERK activation dynamics in response to growth factor pulses using COPASI.
The ERK MAP kinase network responds to both epidermal (EGF) and neuronal growth factor (NGF). Depending on the activation dynamics, cell fates such as proliferation or differentiation can be induced. Growth factor pulses of different duration, frequency and concentration result in either transient or sustained ERK activity, which is enabled by multiple feedback mechanisms in the signalling pathway.
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