Project: Tracking of Calcium Waves in Plant Roots
Plants respond to a sudden change of environmental conditions and bacterial challenges by increased activity of intracellular signaling by calcium ions (Ca2+). For the model plant Arabidopsis thaliana it could be shown that Ca2+ signals propagate in waves through the root and show stimulus-specific signatures, if the plant is stimulated by salt or bacterial peptides.
We investigate the propagation of Ca2+ signaling waves through the root by applying mathematical and computational methods. The aim is to understand how cell-to-cell communication works in plants and how they encode and decode stimulus-specific information in these Ca2+ waves.
We analyze time-lapse movies of the root after stimulation with an external stimulus to determine characteristic parameters like start time, duration and intensity of the signaling. For this purpose, we implemented an automated image analysis to quantify the intracellular Ca2+ signaling.
This research project is a joint project between the Grossmann lab at COS in Heidelberg (www.grossmann-lab.org – now at Heinrich Heine Universität Düsseldorf: https://www.icib.hhu.de/) and our group. My work focuses on the software development for the image processing, the cellular automaton modeling and the data analysis. I am coding scripts in the programming languages R, MATLAB and C/C++.
Funding and Supervision
My project is funded by the Innovation Fund FRONTIER (German Excellence Initiative) and by the BIOMS (Center for Modelling and Simulations in the Biosciences) program. Supervision is granted by Dr. Jürgen Pahle (Heidelberg University) and Prof. Ursula Kummer (Heidelberg University).
- Tutor in the exercises for the lecture Mathematics for Systems Biology
- Lecturer in the R-programming course Scientific programming with R for biologists and molecular biotechnologists
- Supervision of interns
- P. Neubert, A. Halim, M. Zauser, A. Essig, H.J. Joshi, E. Zatorska, I.S.B. Larsen, M. Loibl, J. Castells-Ballester, M. Aebi, H. Clausen and S. Strahl (2016)
Mapping the O-mannose glycoproteome in Saccharomyces cerevisiae.
Molecular & Cellular Proteomics, doi:10.1074/mcp.M115.057505
|since 2016||PhD student in the Biological Information Processing (BIP) Group, Heidelberg University|
|2013‑2015||Master of Science (MSc) Molecular Biosciences, Systems Biology, Heidelberg University|
|2010‑2013||Bachelor of Science (BSc) Biowissenschaften, Heidelberg University|
Im Neuenheimer Feld 267
69120 Heidelberg, Germany
Phone: +49 (0) 6221-54-51328